{"id":8651,"date":"2024-04-22T09:13:17","date_gmt":"2024-04-22T01:13:17","guid":{"rendered":"https:\/\/www.1ai.net\/?p=8651"},"modified":"2024-04-22T09:13:17","modified_gmt":"2024-04-22T01:13:17","slug":"ai-%e5%b0%86%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e6%8f%90%e9%80%9f%e5%8d%81%e5%80%8d%ef%bc%8c%e5%8f%af%e8%af%86%e5%88%ab%e9%98%bb%e6%ad%a2%e8%af%a5%e7%97%85","status":"publish","type":"post","link":"https:\/\/www.1ai.net\/en\/8651.html","title":{"rendered":"AI accelerates Parkinson&#039;s disease drug design tenfold, identifying small molecules that prevent protein aggregation characteristic of the disease"},"content":{"rendered":"<p data-vmark=\"b0d8\">\u636e\u82f1\u56fd\u5251\u6865\u5927\u5b66\u5b98\u7f51\uff0c\u8be5\u6821\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u4eba\u5de5\u667a\u80fd\u6280\u672f\u5927\u5e45\u52a0\u5feb\u4e86<a href=\"https:\/\/www.1ai.net\/en\/tag\/%e5%b8%95%e9%87%91%e6%a3%ae\" title=\"\u3010\u67e5\u770b\u542b\u6709[\u5e15\u91d1\u68ee]\u6807\u7b7e\u7684\u6587\u7ae0\u3011\" target=\"_blank\" rel=\"noopener\">\u5e15\u91d1\u68ee<\/a>\u75c5\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\u8fdb\u7a0b\u3002<\/p>\n<p data-vmark=\"a2e8\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-8652\" title=\"3a44d115-04c9-40b0-9dfe-799b501bfe08\" src=\"https:\/\/www.1ai.net\/wp-content\/uploads\/2024\/04\/3a44d115-04c9-40b0-9dfe-799b501bfe08.png\" alt=\"3a44d115-04c9-40b0-9dfe-799b501bfe08\" width=\"927\" height=\"1057\" \/><\/p>\n<p data-vmark=\"3fbb\">\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u5e76\u4f7f\u7528\u4e86\u4e00\u79cd\u57fa\u4e8e <a href=\"https:\/\/www.1ai.net\/en\/tag\/ai\" title=\"\u3010\u67e5\u770b\u542b\u6709[AI]\u6807\u7b7e\u7684\u6587\u7ae0\u3011\" target=\"_blank\" rel=\"noopener\">AI<\/a> \u7684\u7b56\u7565\uff0c<span class=\"accentTextColor\">\u4ece\u800c\u6765\u8bc6\u522b\u963b\u6b62 \u03b1-\u7a81\u89e6\u6838\u86cb\u767d<\/span>\uff08IT\u4e4b\u5bb6\u6ce8\uff1a\u5e15\u91d1\u68ee\u75c5\u7684\u7279\u5f81\u86cb\u767d\uff09<span class=\"accentTextColor\">\u805a\u96c6\u7684\u5c0f\u5206\u5b50<\/span>\u3002\u8fd9\u4e5f\u662f\u5bfb\u627e\u5e15\u91d1\u68ee\u75c5\u6f5c\u5728\u6cbb\u7597\u65b9\u6cd5\u7684\u4e00\u6761\u9014\u5f84\u3002<\/p>\n<p data-vmark=\"2e6a\">\u8be5\u56e2\u961f<span class=\"accentTextColor\">\u901a\u8fc7\u673a\u5668\u5b66\u4e60\u6280\u672f\uff0c\u5feb\u901f\u7b5b\u9009\u4e86\u4e00\u4e2a\u5305\u542b\u6570\u767e\u4e07\u4e2a\u6761\u76ee\u7684\u5316\u5b66\u5e93<\/span>\uff0c\u4ee5\u8bc6\u522b\u4e0e\u6dc0\u7c89\u6837\u86cb\u767d\u805a\u96c6\u4f53\u7ed3\u5408\u5e76\u963b\u6b62\u5176\u589e\u6b96\u7684\u5c0f\u5206\u5b50\uff0c\u6700\u7ec8\u786e\u5b9a\u4e86 5 \u79cd\u9ad8\u5ea6\u6709\u6548\u7684\u5316\u5408\u7269\u4f9b\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<p data-vmark=\"b8b7\">\u51ed\u501f\u4eba\u5de5\u667a\u80fd\u201c\u501f\u529b\u201d\uff0c<span class=\"accentTextColor\">\u521d\u59cb\u7b5b\u67e5\u8fc7\u7a0b\u73b0\u5df2\u88ab\u52a0\u5feb\u4e86 10 \u500d\uff0c\u6210\u672c\u4e5f\u7f29\u51cf\u81f3\u539f\u672c\u7684\u5343\u5206\u4e4b\u4e00<\/span>\uff0c\u4f7f\u7814\u53d1\u51fa\u5e15\u91d1\u68ee\u75c5\u6f5c\u5728\u7597\u6cd5\u7684\u901f\u5ea6\u76f8\u6bd4\u4ee5\u5f80\u663e\u8457\u52a0\u5feb\u3002\u636e\u8be5\u7814\u7a76\u7684\u9886\u5bfc\u8005\u7c73\u6b47\u5c14\u30fb\u6587\u5fb7\u9c81\u65af\u79d1\u6d1b\u6559\u6388\u4ecb\u7ecd\uff0c<span class=\"accentTextColor\">\u673a\u5668\u5b66\u4e60\u6b63\u5728\u5bf9\u836f\u7269\u53d1\u73b0\u8fc7\u7a0b\u4ea7\u751f\u5f71\u54cd\uff0c\u5b83\u52a0\u5feb\u4e86\u8bc6\u522b\u6700\u6709\u524d\u9014\u7684\u5019\u9009\u836f\u7684\u8fc7\u7a0b<\/span>\u3002\u7531\u4e8e\u65f6\u95f4\u548c\u6210\u672c\u5927\u5e45\u51cf\u5c11\uff0c\u672a\u6765\u53ef\u5b9e\u884c\u591a\u4e2a\u836f\u7269\u5f00\u53d1\u8ba1\u5212\u3002<\/p>\n<p data-vmark=\"42eb\">\u7814\u7a76\u6210\u679c\u5df2\u7ecf\u53d1\u8868\u5728\u300a\u81ea\u7136-\u5316\u5b66\u751f\u7269\u5b66\u300b\u6742\u5fd7\u4e0a\uff0c<a href=\"https:\/\/www.nature.com\/articles\/s41589-024-01580-x\" target=\"_blank\" rel=\"noopener\">\u70b9\u6b64\u524d\u5f80<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the official website of the University of Cambridge in the UK, researchers at the university have dramatically accelerated the process of developing treatments for Parkinson's disease through artificial intelligence technology. The researchers designed and used an AI-based strategy so as to identify small molecules that prevent the aggregation of \u03b1-synuclein (IT House note: the characteristic protein of Parkinson's disease). This is also a way to find potential treatments for Parkinson's disease. Using machine learning techniques, the team quickly screened a chemical library of millions of entries to identify small molecules that bind to amyloid aggregates and prevent their proliferation, ultimately identifying five highly effective compounds for further study. With the \"power\" of artificial intelligence, the initial screening process has now been sped up 10-fold and reduced to one-thousandth of the original cost, enabling the development of a Parkinson's disease<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[146],"tags":[411,2329,2330],"collection":[],"class_list":["post-8651","post","type-post","status-publish","format-standard","hentry","category-news","tag-ai","tag-2329","tag-2330"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/posts\/8651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/comments?post=8651"}],"version-history":[{"count":0,"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/posts\/8651\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/media?parent=8651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/categories?post=8651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/tags?post=8651"},{"taxonomy":"collection","embeddable":true,"href":"https:\/\/www.1ai.net\/en\/wp-json\/wp\/v2\/collection?post=8651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}